Yeast is indica weed the new hemp analogue

indica weedMankind, as a community, would lose a lot, not create nature yeast fungi. Baking yeast has been giving us lush bread for millennia. And we don't even want to imagine a world without beer and wine, in which yeast turns sugar into alcohol.

But now researchers have turned to yeast to do something incredible: make them produce cannabinoids - THC and CBD. Including cannabis genes in the DNA of the yeast fungi, they've turned them into factories of active cannabis components. In a broader sense, many other cannabis components can be obtained using this technique to better understand the real potential of each of them individually, and of plants as a whole.

Technology for producing cannabinoids using genetically modified yeasts

The process is as follows: two different types of yeast produce either THC or CBD, depending on which DNA fragment is embedded in them. It is important to note that both carry the cannabis genes that produce CBGA (cannabigerolic acid). "CBGA is a kind of basic cannabinoid that is the primary, i.e. semi-finished product for the synthesis of other cannabinoids," says Jay Kissling, a chemist engineer at the University of California at Berkeley who co-authored an article in Nature detailing the process technique.

indica weedTo eventually produce THC, these fungi first produce CBGA, which is then converted to THCA (THCA - tetrahydrocinnabinolic acid) by a special yeast enzyme. In yeast "tuned" to CBDA production, their specific enzyme converts the mother cannabinoid CBGA into CBDA (CBDA is cannabidiolic acid). We now have THCA and CBDA, which are converted to THC and CBDA using heat.

The end product is indica no different from that produced by the cannabis plant. But if you eat fresh cannabis, you are unlikely to get the desired effect as THCA has no psychoactive effect. THCA turns into an active THCA when exposed to high temperatures - for example, when smoking, using a vaporizer or baking. Although some percentage of THCA turns into THCA over time, during drying and soaking, these are very small amounts. Edible products such as candies or beverages work because manufacturers convert THCA to THCA through a decarboxing process.

The reason why researchers and companies are interested in alternative ways of producing cannabinoids is that working with an original plant is time-consuming and costly. Growing cannabis is time, water and electricity consuming (if it is cultivated indoors). Removing some cannabinoids from the inflorescences also requires some effort. For example, when trying to obtain a chemically pure CBD, it is possible that the extract will be contaminated with THC. This is of particular concern when OBD is intended to be used as a drug - it has been shown, for example, to be extremely effective in treating epilepsy.

Copyright 2004-2005 All Rights Reserved.